Twin studies: past, present and future
p. 17-18
Texte intégral
1There are few aspects of human behavior that have not been investigated using the classical twin design. Beyond the classical twin design, the trend to investigate aspects of human behavior in increasingly large samples of twins and their family members is continuing and shows promise for the detection of non-additive genetic effects, genotype-environment correlations and genotype-by-sex and by-age interactions.
2I will review recent studies from psychology, behavioral sciences and psychiatry. In addition to typical traits studied by psychologists, the past few years saw studies of voting behavior (Hatemi et al., 2007), willingness to take economic risks (Zhong, et al., 2009), truancy in high school (van der Aa et al., 2009) outcomes in the classic trust game (Cesarini et al., 2008), humor (Vernon et al., 2008), self-reported G-spot in women (Burri et al. 2009), and sexual performance during first intercourse in men (Santtila et al., 2009).
3In psychiatry, childhood psychopathology is studied in longitudinal samples, there is an increasing interest in personality disorders such as borderline personality disorder (Aggen et al., 2009; Distel et al., 2009), adult ADHD (Boomsma et al., 2010), obsessive compulsive disorder (Grootheest et al., 2009) and eating disorders, for example. Over the past few years, we also saw an increase in the number of studies that combine imaging approaches with clever selection of twins concordant or discordant for major psychiatric disorders.
4To conclude my talk, I will discuss whether there is room for the classical twin design in the current era of molecular genetic studies. The answer is yes: the classical twin design holds promises for the study of gene expression, epigenetics, metabolomic and proteomic projects and gene-environment interaction. The study of special groups, such as monozygotic discordant twin pairs, can be a very powerful approach to search for causal genes underlying monogenetic and complex disorders.
Bibliographie
Des DOI sont automatiquement ajoutés aux références bibliographiques par Bilbo, l’outil d’annotation bibliographique d’OpenEdition. Ces références bibliographiques peuvent être téléchargées dans les formats APA, Chicago et MLA.
Format
- APA
- Chicago
- MLA
Cette bibliographie a été enrichie de toutes les références bibliographiques automatiquement générées par Bilbo en utilisant Crossref.
References
10.1017/S0033291709005807 :Aggen, S.H., Neale, M.C., Røysamb, E., Reichborn-Kjennerud, T., Kendler, K.S. (2009). A psychometric evaluation of the DSM-IV borderline personality disorder criteria: age and sex moderation of criterion functioning. Psychological Medicine, 39, 1967-1978.
10.1371/journal.pone.0010621 :Boomsma, D.I., Saviouk, V., Hottenga, J.J., Distel, M.A., de Moor, M.H. et al. (2010). Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS One. May 12, 5 (5): e10621.
Burri, A.V., Cherkas, L., Spector, T.D. (2010). Genetic and environmental influences on self-reported G-spots in women: a twin study. Journal of Sex Medicine, 7, 1842-1852. Epub 2009 Dec 30.
10.1073/pnas.0710069105 :Cesarini, D., Dawes, C.T., Fowler, J.H., Johannesson, M., Lichtenstein, P., Wallace, B. (2008). Heritability of cooperative behavior in the trust game. Proceeding of the National Academy of Science U S A., 105, 3721-3726.
Distel, M.A., Trull, T.J., Willemsen, G., Vink, J.M., Derom, C.A., et al. (2009). The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. Biological Psychiatry, 66, 1131-1138.
Hatemi, P.K., Medland, S.E., Morley, K.I., Heath, A.C., Martin, N.G. (2007). The genetics of voting: an Australian twin study. Behavior Genetics, 37, 435-48
10.1111/j.1464-410X.2009.09040.x :Jern, P., Santtila, P., Johansson, A., Sandnabba, N.K. (2010). Genetic and environmental effects on the continuity of ejaculatory dysfunction. Bristish Journal of Urology International, 105, 1698-1704.
Van der Aa, N., Rebollo-Mesa, I., Willemsen, G., Boomsma, D.I., Bartels, M. (2009). Frequency of truancy at high school: evidence for genetic and twin specific shared environmental influences. Journal Adolescent Health, 45, 579-586.
Van Grootheest, D.S., Cath, D., Hottenga, J. J., Beekman, A.T., Boomsma, D.I. (2009). Genetic factors underlie stability of obsessive-compulsive symptoms. Twin Research and Human Genetics, 12, 411-419.
Vernon, P.A., Martin, R.A., Schermer, J.A., Cherkas, L.F., Spector, T.D. (2008). Genetic and environmental contributions to humor styles: a replication study. Twin Research and Human Genetics, 11, 44-7.
10.1375/twin.12.1.103 :Zhong, S., Chew, S.H., Set, E., Zhang, J., Xue, H. et al. (2009). The heritability of attitude toward economic risk. Twin Research and Human Genetics, 12, 103-7.
Le texte seul est utilisable sous licence Licence OpenEdition Books. Les autres éléments (illustrations, fichiers annexes importés) sont « Tous droits réservés », sauf mention contraire.
Vive(nt) les différences
Ce livre est diffusé en accès ouvert freemium. L’accès à la lecture en ligne est disponible. L’accès aux versions PDF et ePub est réservé aux bibliothèques l’ayant acquis. Vous pouvez vous connecter à votre bibliothèque à l’adresse suivante : https://0-freemium-openedition-org.catalogue.libraries.london.ac.uk/oebooks
Si vous avez des questions, vous pouvez nous écrire à access[at]openedition.org
Référence numérique du chapitre
Format
Référence numérique du livre
Format
1 / 3